FGFR2 R625T
Gene Variant Detail

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Gene FGFR2
Variant R625T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 R625T lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). R625T has been identified in sequencing studies (PMID: 17344846), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, May 2026).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 R625T

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Transcript NM_000141.5
gDNA chr10:g.121488103_121488104delCGinsAC
cDNA c.1873_1874delCGinsAC
Protein p.R625T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017015924.3 chr10:g.121485428C>G c.1874G>C p.R625T RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121483789C>G c.1874G>C p.R625T RefSeq GRCh38/hg38
NM_001144914 chr10:g.121483789C>G c.1874G>C p.R625T RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121488103_121488104delCGinsAC c.1873_1874delCGinsAC p.R625T RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121488103_121488104delCGinsAC c.1873_1874delCGinsAC p.R625T RefSeq GRCh38/hg38
NM_000141 chr10:g.121488103_121488104delCGinsGT c.1873_1874delCGinsAC p.R625T RefSeq GRCh38/hg38
XM_017015924.2 chr10:g.121485428C>G c.1874G>C p.R625T RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121483789C>G c.1874G>C p.R625T RefSeq GRCh38/hg38
XM_017015924 chr10:g.121485428C>G c.1874G>C p.R625T RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries