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Gene FGFR2
Variant S252L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 S252L lies within the extracellular domain of the Fgfr2 protein (UniProt.org). S252L results in altered affinity for Fgfr ligands in in vitro assays when combined with A315S (PMID: 15282208), but has not been characterized individually and therefore, its effect on Fgfr2 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 exon7 FGFR2 S252L

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Transcript NM_000141.5
gDNA chr10:g.121520163G>A
cDNA c.755C>T
Protein p.S252L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320658.2 chr10:g.121520163G>A c.755C>T p.S252L RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121520163G>A c.755C>T p.S252L RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121520163G>A c.755C>T p.S252L RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121520163G>A c.755C>T p.S252L RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121520163G>A c.755C>T p.S252L RefSeq GRCh38/hg38
NM_001320658 chr10:g.121520163G>A c.755C>T p.S252L RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121520163G>A c.755C>T p.S252L RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520163G>A c.755C>T p.S252L RefSeq GRCh38/hg38
NM_000141 chr10:g.121520163G>A c.755C>T p.S252L RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121520163G>A c.755C>T p.S252L RefSeq GRCh38/hg38
NM_001144913 chr10:g.121520163G>A c.755C>T p.S252L RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121520163G>A c.755C>T p.S252L RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520163G>A c.755C>T p.S252L RefSeq GRCh38/hg38
NM_022970 chr10:g.121520163G>A c.755C>T p.S252L RefSeq GRCh38/hg38
NM_001144917 chr10:g.121520163G>A c.755C>T p.S252L RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References