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Gene FGFR2
Variant S267P
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 S267P lies within Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). S267P has been identified in sequencing studies (PMID: 11325814), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 exon7 FGFR2 S267P

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Transcript NM_000141.5
gDNA chr10:g.121520119A>G
cDNA c.799T>C
Protein p.S267P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144917.1 chr10:g.121520119A>G c.799T>C p.S267P RefSeq GRCh38/hg38
NM_001144917 chr10:g.121520119A>G c.799T>C p.S267P RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121520119A>G c.799T>C p.S267P RefSeq GRCh38/hg38
NM_000141 chr10:g.121520119A>G c.799T>C p.S267P RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121520119A>G c.799T>C p.S267P RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121520119A>G c.799T>C p.S267P RefSeq GRCh38/hg38
NM_001320658 chr10:g.121520119A>G c.799T>C p.S267P RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121520119A>G c.799T>C p.S267P RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121520119A>G c.799T>C p.S267P RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121520119A>G c.799T>C p.S267P RefSeq GRCh38/hg38
NM_001144913 chr10:g.121520119A>G c.799T>C p.S267P RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520119A>G c.799T>C p.S267P RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520119A>G c.799T>C p.S267P RefSeq GRCh38/hg38
NM_022970 chr10:g.121520119A>G c.799T>C p.S267P RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121520119A>G c.799T>C p.S267P RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 S267P Cancer of Unknown Primary predicted - sensitive Erdafitinib Case Reports/Case Series Actionable In a clinical case study, Balversa (erdafitinib) treatment resulted in a partial response with a progression-free survival of 7 months and best objective response of -40% in a patient with cancer of unknown primary harboring FGFR2 S267P (PMID: 39226398). 39226398