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Gene FGFR2
Variant V392A
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR2 V392A lies within the transmembrane domain of the Fgfr2 protein (UniProt.org). V392A results in decreased proliferation relative to wild-type Fgfr2 in a competition assay but increased transformation activity in cultured cells (PMID: 34272467), and therefore, is predicted to lead to a gain of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 V392A

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Transcript NM_000141.5
gDNA chr10:g.121515229A>G
cDNA c.1175T>C
Protein p.V392A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320658.1 chr10:g.121515229A>G c.1175T>C p.V392A RefSeq GRCh38/hg38
XM_024447888.1 chr10:g.121503841A>G c.1175T>C p.V392A RefSeq GRCh38/hg38
NM_001320658 chr10:g.121515229A>G c.1175T>C p.V392A RefSeq GRCh38/hg38
XM_024447888.2 chr10:g.121503841A>G c.1175T>C p.V392A RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121515229A>G c.1175T>C p.V392A RefSeq GRCh38/hg38
NM_000141 chr10:g.121515229A>G c.1175T>C p.V392A RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121515229A>G c.1175T>C p.V392A RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121515229A>G c.1175T>C p.V392A RefSeq GRCh38/hg38
XM_017015922 chr10:g.121503841A>G c.1175T>C p.V392A RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries