Gene Variant Detail

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Gene FGFR2
Variant V395D
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR2 V395D lies within the transmembrane domain of the Fgfr2 protein (UniProt.org). V395D results in proliferation similar to wild-type Fgfr2 in a competition assay and transformation activity similar to wild-type in cultured cells (PMID: 34272467), and therefore, is predicted to have no effect on Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 V395D

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Transcript NM_000141.5
gDNA chr10:g.121515220A>T
cDNA c.1184T>A
Protein p.V395D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320658 chr10:g.121515220A>T c.1184T>A p.V395D RefSeq GRCh38/hg38
NM_000141 chr10:g.121515220A>T c.1184T>A p.V395D RefSeq GRCh38/hg38
NM_001144918.2 chr10:g.121500852A>T c.1184T>A p.V395D RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121515220A>T c.1184T>A p.V395D RefSeq GRCh38/hg38
NM_001144918 chr10:g.121500852A>T c.1184T>A p.V395D RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121515220A>T c.1184T>A p.V395D RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121515220A>T c.1184T>A p.V395D RefSeq GRCh38/hg38
NM_001144918.1 chr10:g.121500852A>T c.1184T>A p.V395D RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121515220A>T c.1184T>A p.V395D RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References