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Gene FGFR2
Variant Y281C
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 Y281C lies within Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). Y281C has been identified in the scientific literature (PMID: 26003532, PMID: 29104507), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 exon7 FGFR2 Y281C

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Transcript NM_000141.5
gDNA chr10:g.121520076T>C
cDNA c.842A>G
Protein p.Y281C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_022970.3 chr10:g.121520076T>C c.842A>G p.Y281C RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121520076T>C c.842A>G p.Y281C RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121520076T>C c.842A>G p.Y281C RefSeq GRCh38/hg38
NM_001144917 chr10:g.121520076T>C c.842A>G p.Y281C RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121520076T>C c.842A>G p.Y281C RefSeq GRCh38/hg38
NM_000141 chr10:g.121520076T>C c.842A>G p.Y281C RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121520076T>C c.842A>G p.Y281C RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121520076T>C c.842A>G p.Y281C RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520076T>C c.842A>G p.Y281C RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121520076T>C c.842A>G p.Y281C RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520076T>C c.842A>G p.Y281C RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121520076T>C c.842A>G p.Y281C RefSeq GRCh38/hg38
NM_022970 chr10:g.121520076T>C c.842A>G p.Y281C RefSeq GRCh38/hg38
NM_001320658 chr10:g.121520076T>C c.842A>G p.Y281C RefSeq GRCh38/hg38
NM_001144913 chr10:g.121520076T>C c.842A>G p.Y281C RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
FGFR2 Y281C unknown