FGFR3 D646Y
Gene Variant Detail

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Gene FGFR3
Variant D646Y
Impact List missense
Protein Effect no effect
Gene Variant Descriptions FGFR3 D646Y lies within the protein kinase domain of the Fgfr3 protein (UniProt.org). D646Y demonstrates autophosphorylation and substrate phosphorylation similar to the level of wild-type Fgfr3 in cell culture (PMID: 26992226).
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 D646Y

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Transcript NM_000142.5
gDNA chr4:g.1806150G>T
cDNA c.1936G>T
Protein p.D646Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713873.2 chr4:g.1806150G>T c.1936G>T p.D646Y RefSeq GRCh38/hg38
NM_000142 chr4:g.1806150G>T c.1936G>T p.D646Y RefSeq GRCh38/hg38
XM_006713873.1 chr4:g.1806150G>T c.1936G>T p.D646Y RefSeq GRCh38/hg38
XM_006713873 chr4:g.1806150G>T c.1936G>T p.D646Y RefSeq GRCh38/hg38
NM_000142.5 chr4:g.1806150G>T c.1936G>T p.D646Y RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.1806150G>T c.1936G>T p.D646Y RefSeq GRCh38/hg38
NM_000142.4 chr4:g.1806150G>T c.1936G>T p.D646Y RefSeq GRCh38/hg38
NM_022965.3 chr4:g.1806932G>T c.1936G>T p.D646Y RefSeq GRCh38/hg38
NM_022965.4 chr4:g.1806932G>T c.1936G>T p.D646Y RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.1806150G>T c.1936G>T p.D646Y RefSeq GRCh38/hg38
NM_022965 chr4:g.1806932G>T c.1936G>T p.D646Y RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References