FGFR3 A500T - Gene Variant Detail

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Gene FGFR3
Variant A500T
Impact List missense
Protein Effect no effect
Gene Variant Descriptions FGFR3 A500T lies within the protein kinase domain of the Fgfr3 protein (UniProt.org). A500T demonstrates autophosphorylation and substrate phosphorylation similar to wild-type Fgfr3 in cell culture (PMID: 26992226).
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 A500T

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Transcript NM_000142.5
gDNA chr4:g.1805440G>A
cDNA c.1498G>A
Protein p.A500T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354810.2 chr4:g.1805437G>A c.1498G>A p.A500T RefSeq GRCh38/hg38
XM_006713872 chr4:g.1805437G>A c.1498G>A p.A500T RefSeq GRCh38/hg38
NM_000142.4 chr4:g.1805440G>A c.1498G>A p.A500T RefSeq GRCh38/hg38
XM_011513422 chr4:g.1805437G>A c.1498G>A p.A500T RefSeq GRCh38/hg38
XM_047449822.1 chr4:g.1805437G>A c.1498G>A p.A500T RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.1805440G>A c.1498G>A p.A500T RefSeq GRCh38/hg38
NM_000142 chr4:g.1805440G>A c.1498G>A p.A500T RefSeq GRCh38/hg38
XM_011513422.2 chr4:g.1805437G>A c.1498G>A p.A500T RefSeq GRCh38/hg38
NM_001354809.2 chr4:g.1805437G>A c.1498G>A p.A500T RefSeq GRCh38/hg38
XM_006713873.2 chr4:g.1805440G>A c.1498G>A p.A500T RefSeq GRCh38/hg38
XM_011513422.1 chr4:g.1805437G>A c.1498G>A p.A500T RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.1805440G>A c.1498G>A p.A500T RefSeq GRCh38/hg38
XM_006713873.1 chr4:g.1805440G>A c.1498G>A p.A500T RefSeq GRCh38/hg38
XM_006713873 chr4:g.1805440G>A c.1498G>A p.A500T RefSeq GRCh38/hg38
NM_000142.5 chr4:g.1805440G>A c.1498G>A p.A500T RefSeq GRCh38/hg38
NM_001354809.1 chr4:g.1805437G>A c.1498G>A p.A500T RefSeq GRCh38/hg38
NM_001354810.1 chr4:g.1805437G>A c.1498G>A p.A500T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References