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Gene FGFR3
Variant E627D
Impact List missense
Protein Effect no effect
Gene Variant Descriptions FGFR3 E627D lies within the protein kinase domain of the Fgfr3 protein (UniProt.org). E627D demonstrates autophosphorylation and substrate phosphorylation similar to wild-type Fgfr3 in cell culture (PMID: 26992226).
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 E627D

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Transcript NM_000142.5
gDNA chr4:g.1806095G>C
cDNA c.1881G>C
Protein p.E627D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047449823.1 chr4:g.1806095G>C c.1881G>C p.E627D RefSeq GRCh38/hg38
NM_000142.4 chr4:g.1806095G>C c.1881G>C p.E627D RefSeq GRCh38/hg38
NM_000142.5 chr4:g.1806095G>C c.1881G>C p.E627D RefSeq GRCh38/hg38
XM_006713873.1 chr4:g.1806095G>C c.1881G>C p.E627D RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.1806095G>C c.1881G>C p.E627D RefSeq GRCh38/hg38
XM_006713873.2 chr4:g.1806095G>C c.1881G>C p.E627D RefSeq GRCh38/hg38
NM_000142 chr4:g.1806095G>C c.1881G>C p.E627D RefSeq GRCh38/hg38
XM_006713873 chr4:g.1806095G>C c.1881G>C p.E627D RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References