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Gene FGFR3
Variant N653H
Impact List missense
Protein Effect no effect
Gene Variant Descriptions FGFR3 N653H lies within the protein kinase domain of the Fgfr3 protein (UniProt.org). N653H demonstrates autophosphorylation and substrate phosphorylation similar to wild-type Fgfr3 in cell culture (PMID: 26992226).
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 N653H

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Transcript NM_000142.5
gDNA chr4:g.1806171A>C
cDNA c.1957A>C
Protein p.N653H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713873.1 chr4:g.1806171A>C c.1957A>C p.N653H RefSeq GRCh38/hg38
NM_000142.5 chr4:g.1806171A>C c.1957A>C p.N653H RefSeq GRCh38/hg38
XM_006713873.2 chr4:g.1806171A>C c.1957A>C p.N653H RefSeq GRCh38/hg38
NM_000142 chr4:g.1806171A>C c.1957A>C p.N653H RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.1806171A>C c.1957A>C p.N653H RefSeq GRCh38/hg38
XM_006713873 chr4:g.1806171A>C c.1957A>C p.N653H RefSeq GRCh38/hg38
NM_000142.4 chr4:g.1806171A>C c.1957A>C p.N653H RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.1806171A>C c.1957A>C p.N653H RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
FGFR3 N653H no effect