FGFR3 R669G
Gene Variant Detail

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Gene FGFR3
Variant R669G
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FGFR3 R669G lies within the protein kinase domain of the Fgfr3 protein (UniProt.org). R669G results in increased Fgfr3 autophosphorylation and substrate phosphorylation in cell culture (PMID: 26992226).
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 act mut FGFR3 R669G

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Transcript NM_000142.5
gDNA chr4:g.1806302C>G
cDNA c.2005C>G
Protein p.R669G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000142.4 chr4:g.1806302C>G c.2005C>G p.R669G RefSeq GRCh38/hg38
XM_006713873.1 chr4:g.1806302C>G c.2005C>G p.R669G RefSeq GRCh38/hg38
NM_000142 chr4:g.1806302C>G c.2005C>G p.R669G RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.1806302C>G c.2005C>G p.R669G RefSeq GRCh38/hg38
XM_006713873 chr4:g.1806302C>G c.2005C>G p.R669G RefSeq GRCh38/hg38
NM_000142.5 chr4:g.1806302C>G c.2005C>G p.R669G RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.1806302C>G c.2005C>G p.R669G RefSeq GRCh38/hg38
XM_006713873.2 chr4:g.1806302C>G c.2005C>G p.R669G RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References