FGFR3 G382D
Gene Variant Detail

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Gene FGFR3
Variant G382D
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR3 G382D lies within the transmembrane domain of the Fgfr3 protein (UniProt.org). G382D is not transforming but results in constitutive activation of Fgfr3 and downstream signaling in culture (PMID: 11429702), and therefore, is predicted to lead to a gain of Fgfr3 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 act mut FGFR3 G382D

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Transcript NM_000142.5
gDNA chr4:g.1804399G>A
cDNA c.1145G>A
Protein p.G382D
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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