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Gene FGFR3
Variant N540T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR3 N540T lies within the protein kinase domain of the Fgfr3 protein (UniProt.org). N540T has been identified in sequencing studies (PMID: 10425034), but has not been biochemically characterized and therefore, its effect on Fgfr3 protein function is unknown (PubMed, Mar 2024).
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 N540T

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Transcript NM_000142.5
gDNA chr4:g.1805643A>C
cDNA c.1619A>C
Protein p.N540T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713870.1 chr4:g.1805634A>C c.1619A>C p.N540T RefSeq GRCh38/hg38
XM_006713873.1 chr4:g.1805643A>C c.1619A>C p.N540T RefSeq GRCh38/hg38
XM_006713873.2 chr4:g.1805643A>C c.1619A>C p.N540T RefSeq GRCh38/hg38
NM_000142.5 chr4:g.1805643A>C c.1619A>C p.N540T RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.1805643A>C c.1619A>C p.N540T RefSeq GRCh38/hg38
XM_047449821.1 chr4:g.1805634A>C c.1619A>C p.N540T RefSeq GRCh38/hg38
NM_000142 chr4:g.1805643A>C c.1619A>C p.N540T RefSeq GRCh38/hg38
XM_006713870 chr4:g.1805634A>C c.1619A>C p.N540T RefSeq GRCh38/hg38
XM_006713870.2 chr4:g.1805634A>C c.1619A>C p.N540T RefSeq GRCh38/hg38
NM_000142.4 chr4:g.1805643A>C c.1619A>C p.N540T RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.1805643A>C c.1619A>C p.N540T RefSeq GRCh38/hg38
XM_006713873 chr4:g.1805643A>C c.1619A>C p.N540T RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References