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Gene FLT3
Variant K868N
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions FLT3 K868N lies within the protein kinase domain of the Flt3 protein (UniProt.org). K868N inhibits Flt3 autophosphorylation and decreases Erk activity in cell culture (PMID: 27272783).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon21 FLT3 K868N

FLT3 mutant FLT3 inact mut FLT3 K868N

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Transcript NM_004119.3
gDNA chr13:g.28015639C>G
cDNA c.2604G>C
Protein p.K868N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.28015639C>G c.2604G>C p.K868N RefSeq GRCh38/hg38
NM_004119 chr13:g.28015639C>G c.2604G>C p.K868N RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28015639C>G c.2604G>C p.K868N RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References