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Gene CDKN2A
Variant G23fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions CDKN2A G23fs results in a change in the amino acid sequence of the Cdkn2a protein beginning at aa 23 of 156, likely resulting in premature truncation of the functional protein (UniProt.org). G23fs has not been characterized, however, due to the effects of other truncation mutations downstream of G23 (PMID: 9053859, PMID: 8668202), is predicted to lead to a loss of Cdkn2a protein function.
Associated Drug Resistance
Category Variants Paths

CDKN2A mutant CDKN2A inact mut CDKN2A G23fs

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Transcript NM_000077.5
gDNA chr9:g.(21974761_21974762)
cDNA c.(67_66)
Protein p.G23fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000077.4 chr9:g.(21974761_21974762) c.(67_66) p.G23fs RefSeq GRCh38/hg38
NM_001195132.1 chr9:g.(21974761_21974762) c.(67_66) p.G23fs RefSeq GRCh38/hg38
NM_001195132 chr9:g.(21974761_21974762) c.(67_66) p.G23fs RefSeq GRCh38/hg38
XM_011517676.2 chr9:g.(21974761_21974762) c.(67_66) p.G23fs RefSeq GRCh38/hg38
NM_001195132.2 chr9:g.(21974761_21974762) c.(67_66) p.G23fs RefSeq GRCh38/hg38
NM_058197 chr9:g.(21974761_21974762) c.(67_66) p.G23fs RefSeq GRCh38/hg38
NM_000077.5 chr9:g.(21974761_21974762) c.(67_66) p.G23fs RefSeq GRCh38/hg38
XM_011517676.3 chr9:g.(21974761_21974762) c.(67_66) p.G23fs RefSeq GRCh38/hg38
NM_000077 chr9:g.(21974761_21974762) c.(67_66) p.G23fs RefSeq GRCh38/hg38
NM_058197.4 chr9:g.(21974761_21974762) c.(67_66) p.G23fs RefSeq GRCh38/hg38
XM_011517676 chr9:g.(21974761_21974762) c.(67_66) p.G23fs RefSeq GRCh38/hg38
XM_011517675 chr9:g.(21974761_21974762) c.(67_66) p.G23fs RefSeq GRCh38/hg38
XM_011517675.2 chr9:g.(21974761_21974762) c.(67_66) p.G23fs RefSeq GRCh38/hg38
NM_058197.5 chr9:g.(21974761_21974762) c.(67_66) p.G23fs RefSeq GRCh38/hg38
XM_011517675.3 chr9:g.(21974761_21974762) c.(67_66) p.G23fs RefSeq GRCh38/hg38

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Molecular Profile Protein Effect Treatment Approaches
CDKN2A G23fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor