FBXW7 E113D - Gene Variant Detail

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Gene FBXW7
Variant E113D
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FBXW7 E113D does not lie within any known functional domains of the Fbxw7 protein (UniProt.org). E113D has been identified in sequencing studies (PMID: 35770320, PMID: 29483209, PMID: 30959466), but has not been biochemically characterized and therefore, its effect on Fbxw7 protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 E113D

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Transcript NM_033632.3
gDNA chr4:g.152411465C>G
cDNA c.339G>C
Protein p.E113D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011532086.2 chr4:g.152382267C>G c.339G>C p.E113D RefSeq GRCh38/hg38
NM_001257069.1 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_011532084 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_011532086 chr4:g.152382267C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_024454123.1 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_047415899.1 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_011532087.2 chr4:g.152382267C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_047415901.1 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_011532087 chr4:g.152382267C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_024454125.1 chr4:g.152382267C>G c.339G>C p.E113D RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
NM_001349798.2 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_017008362 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_011532084.2 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_047415897.1 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_047415898.1 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_024454124.1 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_011532086.3 chr4:g.152382267C>G c.339G>C p.E113D RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_011532085.3 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_047415900.1 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
NM_001257069.1 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
NM_001349798.1 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_011532087.3 chr4:g.152382267C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_011532083 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_024454121.1 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_047415902.1 chr4:g.152382267C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_011532084.3 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
NM_001257069 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_024454122.1 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_024454123.2 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_011532085.2 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
XM_011532085 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38
NM_033632 chr4:g.152411465C>G c.339G>C p.E113D RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References