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FBXW7 G477S - Gene Variant Detail

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Gene FBXW7
Variant G477S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FBXW7 G477S lies within WD repeat 3 of the Fbxw7 protein (UniProt.org). G477S has been identified in the scientific literature (PMID: 19109228, PMID: 32775947), but has not been biochemically characterized and therefore, its effect on Fbxw7 protein function is unknown (PubMed, Apr 2025).
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 G477S

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Transcript NM_033632.3
gDNA chr4:g.152326221C>T
cDNA c.1429G>A
Protein p.G477S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047415898.1 chr4:g.152326221C>T c.1429G>A p.G477S RefSeq GRCh38/hg38
XM_024454123.2 chr4:g.152326221C>T c.1429G>A p.G477S RefSeq GRCh38/hg38
XM_011532085.3 chr4:g.152326221C>T c.1429G>A p.G477S RefSeq GRCh38/hg38
XM_011532088.2 chr4:g.152323073_152323075delGGAinsAGC c.1429_1431delGGAinsAGC p.G477S RefSeq GRCh38/hg38
XM_024454126.2 chr4:g.152323073_152323075delGGAinsAGC c.1429_1431delGGAinsAGC p.G477S RefSeq GRCh38/hg38
NM_018315.4 chr4:g.152324368_152324370delGGAinsAGC c.1429_1431delGGAinsAGC p.G477S RefSeq GRCh38/hg38
XM_047415899.1 chr4:g.152326221C>T c.1429G>A p.G477S RefSeq GRCh38/hg38
NM_001349798.1 chr4:g.152326221C>T c.1429G>A p.G477S RefSeq GRCh38/hg38
XM_047415901.1 chr4:g.152326221C>T c.1429G>A p.G477S RefSeq GRCh38/hg38
XM_011532088 chr4:g.152323073_152323075delTCCinsGCT c.1429_1431delGGAinsAGC p.G477S RefSeq GRCh38/hg38
XM_011532085 chr4:g.152326221C>T c.1429G>A p.G477S RefSeq GRCh38/hg38
XM_047415900.1 chr4:g.152326221C>T c.1429G>A p.G477S RefSeq GRCh38/hg38
XM_011532084.2 chr4:g.152326221C>T c.1429G>A p.G477S RefSeq GRCh38/hg38
XM_024454123.1 chr4:g.152326221C>T c.1429G>A p.G477S RefSeq GRCh38/hg38
NM_001349798.2 chr4:g.152326221C>T c.1429G>A p.G477S RefSeq GRCh38/hg38
XM_024454124.1 chr4:g.152326221C>T c.1429G>A p.G477S RefSeq GRCh38/hg38
XM_024454122.1 chr4:g.152326221C>T c.1429G>A p.G477S RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152326221C>T c.1429G>A p.G477S RefSeq GRCh38/hg38
XM_011532085.2 chr4:g.152326221C>T c.1429G>A p.G477S RefSeq GRCh38/hg38
XM_024454121.1 chr4:g.152326221C>T c.1429G>A p.G477S RefSeq GRCh38/hg38
XM_047415897.1 chr4:g.152326221C>T c.1429G>A p.G477S RefSeq GRCh38/hg38
XM_011532083 chr4:g.152326221C>T c.1429G>A p.G477S RefSeq GRCh38/hg38
NM_018315 chr4:g.152324368_152324370delTCCinsGCT c.1429_1431delGGAinsAGC p.G477S RefSeq GRCh38/hg38
XM_017008362 chr4:g.152326221C>T c.1429G>A p.G477S RefSeq GRCh38/hg38
XM_024454126.1 chr4:g.152323073_152323075delGGAinsAGC c.1429_1431delGGAinsAGC p.G477S RefSeq GRCh38/hg38
XM_011532084 chr4:g.152326221C>T c.1429G>A p.G477S RefSeq GRCh38/hg38
XM_011532084.3 chr4:g.152326221C>T c.1429G>A p.G477S RefSeq GRCh38/hg38
NM_033632 chr4:g.152326221C>T c.1429G>A p.G477S RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152326221C>T c.1429G>A p.G477S RefSeq GRCh38/hg38
NM_018315.5 chr4:g.152324368_152324370delGGAinsAGC c.1429_1431delGGAinsAGC p.G477S RefSeq GRCh38/hg38

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  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References