ROS1 G666S
Gene Variant Detail

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Gene ROS1
Variant G666S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 G666S lies within fibronectin type-III domain 3 of the Ros1 protein (UniProt.org). G666S has been identified in sequencing studies (PMID: 25801821), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Sep 2025).
Associated Drug Resistance
Category Variants Paths

ROS1 mutant ROS1 G666S

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Transcript NM_002944.3
gDNA chr6:g.117387798C>T
cDNA c.1996G>A
Protein p.G666S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011536051 chr6:g.117387798C>T c.1996G>A p.G666S RefSeq GRCh38/hg38
NM_002944.3 chr6:g.117387798C>T c.1996G>A p.G666S RefSeq GRCh38/hg38
XM_011536051.3 chr6:g.117387798C>T c.1996G>A p.G666S RefSeq GRCh38/hg38
XM_011536051.2 chr6:g.117387798C>T c.1996G>A p.G666S RefSeq GRCh38/hg38
NM_002944.2 chr6:g.117387798C>T c.1996G>A p.G666S RefSeq GRCh38/hg38
NM_002944 chr6:g.117387798C>T c.1996G>A p.G666S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries