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Gene DNMT3A
Variant A121S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions DNMT3A A121S does not lie within any known functional domains of the Dnmt3a protein (UniProt.org). A121S has been identified in the scientific literature (PMID: 26960398), but has not been biochemically characterized and therefore, its effect on Dnmt3a protein function is unknown (PubMed, Jul 2024).
Associated Drug Resistance
Category Variants Paths

DNMT3A mutant DNMT3A A121S

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Transcript NM_022552.5
gDNA chr2:g.25282528C>A
cDNA c.361G>T
Protein p.A121S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320892.2 chr2:g.25282528C>A c.361G>T p.A121S RefSeq GRCh38/hg38
NM_175630 chr2:g.25282528C>A c.361G>T p.A121S RefSeq GRCh38/hg38
XM_047443593.1 chr2:g.25282528C>A c.361G>T p.A121S RefSeq GRCh38/hg38
NM_001320892 chr2:g.25282528C>A c.361G>T p.A121S RefSeq GRCh38/hg38
XM_011532664.2 chr2:g.25282528C>A c.361G>T p.A121S RefSeq GRCh38/hg38
XM_005264175 chr2:g.25282528C>A c.361G>T p.A121S RefSeq GRCh38/hg38
XM_011532664 chr2:g.25282528C>A c.361G>T p.A121S RefSeq GRCh38/hg38
NM_022552.4 chr2:g.25282528C>A c.361G>T p.A121S RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25282528C>A c.361G>T p.A121S RefSeq GRCh38/hg38
NM_022552.5 chr2:g.25282528C>A c.361G>T p.A121S RefSeq GRCh38/hg38
NM_175630.1 chr2:g.25282528C>A c.361G>T p.A121S RefSeq GRCh38/hg38
XM_005264175.6 chr2:g.25282528C>A c.361G>T p.A121S RefSeq GRCh38/hg38
NM_001320892.1 chr2:g.25282528C>A c.361G>T p.A121S RefSeq GRCh38/hg38
NM_175630.1 chr2:g.25282528C>A c.361G>T p.A121S RefSeq GRCh38/hg38
XM_011532664.3 chr2:g.25282528C>A c.361G>T p.A121S RefSeq GRCh38/hg38
XM_005264175.5 chr2:g.25282528C>A c.361G>T p.A121S RefSeq GRCh38/hg38
XM_017003526.1 chr2:g.25282528C>A c.361G>T p.A121S RefSeq GRCh38/hg38
NM_175629 chr2:g.25282528C>A c.361G>T p.A121S RefSeq GRCh38/hg38
XM_017003526 chr2:g.25282528C>A c.361G>T p.A121S RefSeq GRCh38/hg38
NM_022552 chr2:g.25282528C>A c.361G>T p.A121S RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25282528C>A c.361G>T p.A121S RefSeq GRCh38/hg38
XM_017003526.2 chr2:g.25282528C>A c.361G>T p.A121S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References