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Gene FLT3
Variant C184*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions FLT3 C184* results in a premature truncation of the Flt3 protein at amino acid 184 of 993 (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), C184* is predicted to lead to a loss of Flt3 protein function.
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 inact mut FLT3 C184*

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Transcript NM_004119.3
gDNA chr13:g.28052607G>T
cDNA c.552C>A
Protein p.C184*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017020486.2 chr13:g.28052607G>T c.552C>A p.C184* RefSeq GRCh38/hg38
XM_017020486.1 chr13:g.28052607G>T c.552C>A p.C184* RefSeq GRCh38/hg38
NM_004119 chr13:g.28052607G>T c.552C>A p.C184* RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28052607G>T c.552C>A p.C184* RefSeq GRCh38/hg38
XM_017020486 chr13:g.28052607G>T c.552C>A p.C184* RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28052607G>T c.552C>A p.C184* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References