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Gene FLT3
Variant E236*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions FLT3 E236* results in a premature truncation of the Flt3 protein at amino acid 236 of 993 (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), E236* is predicted to lead to a loss of Flt3 protein function.
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 inact mut FLT3 E236*

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Transcript NM_004119.3
gDNA chr13:g.28050131C>A
cDNA c.706G>T
Protein p.E236*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017020486.1 chr13:g.28050131C>A c.706G>T p.E236* RefSeq GRCh38/hg38
XM_017020486.2 chr13:g.28050131C>A c.706G>T p.E236* RefSeq GRCh38/hg38
NM_004119 chr13:g.28050131C>A c.706G>T p.E236* RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28050131C>A c.706G>T p.E236* RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28050131C>A c.706G>T p.E236* RefSeq GRCh38/hg38
XM_017020486 chr13:g.28050131C>A c.706G>T p.E236* RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References