Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Gene | ROS1 |
Variant | S1577Y |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | ROS1 S1577Y lies within fibronectin type-III domain 7 of the Ros1 protein (UniProt.org). S1577Y has been identified in sequencing studies (PMID: 26960398, PMID: 34839264), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Mar 2024). |
Associated Drug Resistance | |
Category Variants Paths |
ROS1 mutant ROS1 S1577Y |
Transcript | NM_002944.3 |
gDNA | chr6:g.117341572G>T |
cDNA | c.4730C>A |
Protein | p.S1577Y |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_002944.2 | chr6:g.117341572G>T | c.4730C>A | p.S1577Y | RefSeq | GRCh38/hg38 |
XM_017011172.1 | chr6:g.117341532_117341533delCAinsAT | c.4730_4731delCAinsAT | p.S1577Y | RefSeq | GRCh38/hg38 |
NM_002944.3 | chr6:g.117341572G>T | c.4730C>A | p.S1577Y | RefSeq | GRCh38/hg38 |
NM_001378891.1 | chr6:g.117341560G>T | c.4730C>A | p.S1577Y | RefSeq | GRCh38/hg38 |
XM_011536052 | chr6:g.117341560G>T | c.4730C>A | p.S1577Y | RefSeq | GRCh38/hg38 |
XM_017011172 | chr6:g.117341532_117341533delTGinsAT | c.4730_4731delCAinsAT | p.S1577Y | RefSeq | GRCh38/hg38 |
XM_011536052.2 | chr6:g.117341560G>T | c.4730C>A | p.S1577Y | RefSeq | GRCh38/hg38 |
XM_017011172.2 | chr6:g.117341532_117341533delCAinsAT | c.4730_4731delCAinsAT | p.S1577Y | RefSeq | GRCh38/hg38 |
NM_002944 | chr6:g.117341572G>T | c.4730C>A | p.S1577Y | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|