Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene ROS1
Variant S1577Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 S1577Y lies within fibronectin type-III domain 7 of the Ros1 protein (UniProt.org). S1577Y has been identified in sequencing studies (PMID: 26960398, PMID: 34839264), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Mar 2024).
Associated Drug Resistance
Category Variants Paths

ROS1 mutant ROS1 S1577Y

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_002944.3
gDNA chr6:g.117341572G>T
cDNA c.4730C>A
Protein p.S1577Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017011172.1 chr6:g.117341532_117341533delCAinsAT c.4730_4731delCAinsAT p.S1577Y RefSeq GRCh38/hg38
XM_011536052 chr6:g.117341560G>T c.4730C>A p.S1577Y RefSeq GRCh38/hg38
NM_002944 chr6:g.117341572G>T c.4730C>A p.S1577Y RefSeq GRCh38/hg38
XM_011536052.2 chr6:g.117341560G>T c.4730C>A p.S1577Y RefSeq GRCh38/hg38
XM_017011172 chr6:g.117341532_117341533delTGinsAT c.4730_4731delCAinsAT p.S1577Y RefSeq GRCh38/hg38
NM_002944.3 chr6:g.117341572G>T c.4730C>A p.S1577Y RefSeq GRCh38/hg38
NM_001378891.1 chr6:g.117341560G>T c.4730C>A p.S1577Y RefSeq GRCh38/hg38
NM_002944.2 chr6:g.117341572G>T c.4730C>A p.S1577Y RefSeq GRCh38/hg38
XM_017011172.2 chr6:g.117341532_117341533delCAinsAT c.4730_4731delCAinsAT p.S1577Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ROS1 S1577Y unknown