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Gene | ROS1 |
Variant | V1979E |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | ROS1 V1979E lies within the protein kinase domain of the Ros1 protein (UniProt.org). V1979E has been identified in sequencing studies (PMID: 26960398), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Apr 2024) |
Associated Drug Resistance | |
Category Variants Paths |
ROS1 mutant ROS1 V1979E |
Transcript | NM_002944.3 |
gDNA | chr6:g.117319872A>T |
cDNA | c.5936T>A |
Protein | p.V1979E |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
XM_011536050.2 | chr6:g.117319898_117319899delTTinsAG | c.5936_5937delTTinsAG | p.V1979E | RefSeq | GRCh38/hg38 |
NM_002944.2 | chr6:g.117319872A>T | c.5936T>A | p.V1979E | RefSeq | GRCh38/hg38 |
XM_011536050.3 | chr6:g.117319898_117319899delTTinsAG | c.5936_5937delTTinsAG | p.V1979E | RefSeq | GRCh38/hg38 |
NM_002944.3 | chr6:g.117319872A>T | c.5936T>A | p.V1979E | RefSeq | GRCh38/hg38 |
NM_002944 | chr6:g.117319872A>T | c.5936T>A | p.V1979E | RefSeq | GRCh38/hg38 |
XM_011536050 | chr6:g.117319898_117319899delAAinsCT | c.5936_5937delTTinsAG | p.V1979E | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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