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Gene ROS1
Variant V1979E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 V1979E lies within the protein kinase domain of the Ros1 protein (UniProt.org). V1979E has been identified in sequencing studies (PMID: 26960398), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Apr 2024)
Associated Drug Resistance
Category Variants Paths

ROS1 mutant ROS1 V1979E

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Transcript NM_002944.3
gDNA chr6:g.117319872A>T
cDNA c.5936T>A
Protein p.V1979E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011536050.3 chr6:g.117319898_117319899delTTinsAG c.5936_5937delTTinsAG p.V1979E RefSeq GRCh38/hg38
NM_002944.3 chr6:g.117319872A>T c.5936T>A p.V1979E RefSeq GRCh38/hg38
XM_011536050.2 chr6:g.117319898_117319899delTTinsAG c.5936_5937delTTinsAG p.V1979E RefSeq GRCh38/hg38
NM_002944 chr6:g.117319872A>T c.5936T>A p.V1979E RefSeq GRCh38/hg38
NM_002944.2 chr6:g.117319872A>T c.5936T>A p.V1979E RefSeq GRCh38/hg38
XM_011536050 chr6:g.117319898_117319899delAAinsCT c.5936_5937delTTinsAG p.V1979E RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References