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Gene TET2
Variant S1870L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TET2 S1870L lies within the catalytic domain of the Tet2 protein (PMID: 24315485). S1870L has been identified in sequencing studies (PMID: 24413737), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

TET2 mutant TET2 S1870L

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Transcript NM_001127208.3
gDNA chr4:g.105276119C>T
cDNA c.5609C>T
Protein p.S1870L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005263082 chr4:g.105276119C>T c.5609C>T p.S1870L RefSeq GRCh38/hg38
NM_001127208.2 chr4:g.105276119C>T c.5609C>T p.S1870L RefSeq GRCh38/hg38
XM_024454102.1 chr4:g.105276119C>T c.5609C>T p.S1870L RefSeq GRCh38/hg38
XM_006714242.4 chr4:g.105276418_105276419delTCinsCT c.5608_5609delTCinsCT p.S1870L RefSeq GRCh38/hg38
NM_001127208.3 chr4:g.105276119C>T c.5609C>T p.S1870L RefSeq GRCh38/hg38
XM_024454103.2 chr4:g.105276119C>T c.5609C>T p.S1870L RefSeq GRCh38/hg38
NM_001127208 chr4:g.105276119C>T c.5609C>T p.S1870L RefSeq GRCh38/hg38
XM_024454102.2 chr4:g.105276119C>T c.5609C>T p.S1870L RefSeq GRCh38/hg38
XM_005263082.4 chr4:g.105276119C>T c.5609C>T p.S1870L RefSeq GRCh38/hg38
XM_006714242.3 chr4:g.105276418_105276419delTCinsCT c.5608_5609delTCinsCT p.S1870L RefSeq GRCh38/hg38
XM_006714242 chr4:g.105276418_105276419delTCinsCT c.5608_5609delTCinsCT p.S1870L RefSeq GRCh38/hg38
XM_024454103.1 chr4:g.105276119C>T c.5609C>T p.S1870L RefSeq GRCh38/hg38
XM_005263082.3 chr4:g.105276119C>T c.5609C>T p.S1870L RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References