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Gene FGFR2
Variant G384E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 G384E lies within the transmembrane domain of the Fgfr2 protein (UniProt.org). G384E has been identified in sequencing studies (PMID: 27147599), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 G384E

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Transcript NM_000141.5
gDNA chr10:g.121515253C>T
cDNA c.1151G>A
Protein p.G384E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017015920.3 chr10:g.121515313C>T c.1151G>A p.G384E RefSeq GRCh38/hg38
NM_001320658 chr10:g.121515253C>T c.1151G>A p.G384E RefSeq GRCh38/hg38
XM_017015920.2 chr10:g.121515313C>T c.1151G>A p.G384E RefSeq GRCh38/hg38
XM_006717708.3 chr10:g.121515313C>T c.1151G>A p.G384E RefSeq GRCh38/hg38
XM_006717710.5 chr10:g.121515313C>T c.1151G>A p.G384E RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121515253C>T c.1151G>A p.G384E RefSeq GRCh38/hg38
XM_006717710.4 chr10:g.121515313C>T c.1151G>A p.G384E RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121515253C>T c.1151G>A p.G384E RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121515253C>T c.1151G>A p.G384E RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121515253C>T c.1151G>A p.G384E RefSeq GRCh38/hg38
XM_006717710 chr10:g.121515313C>T c.1151G>A p.G384E RefSeq GRCh38/hg38
XM_006717708.4 chr10:g.121515313C>T c.1151G>A p.G384E RefSeq GRCh38/hg38
XM_006717708 chr10:g.121515313C>T c.1151G>A p.G384E RefSeq GRCh38/hg38
NM_000141 chr10:g.121515253C>T c.1151G>A p.G384E RefSeq GRCh38/hg38
XM_017015920 chr10:g.121515313C>T c.1151G>A p.G384E RefSeq GRCh38/hg38

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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References