Gene Variant Detail

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Gene CTNNB1
Variant S45_L46insTSS
Impact List insertion
Protein Effect unknown
Gene Variant Descriptions CTNNB1 S45_L46insTSS results in the insertion of three amino acids in the Ctnnb1 protein between amino acids 45 and 46 (UniProt.org). S45_L46insTSS has not been characterized in the scientific literature and therefore, its effect on Ctnnb1 protein function is unknown (PubMed, Sep 2024).
Associated Drug Resistance
Category Variants Paths

CTNNB1 mutant CTNNB1 S45_L46insTSS

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Transcript NM_001098210.2
gDNA chr3:g.41224647_41224648insACAAGCAGC
cDNA c.135_136insACAAGCAGC
Protein p.S45_L46insTSS
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006712985 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
XM_047447477.1 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
NM_001098210.2 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
NM_001098209.2 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
XM_017005738.2 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
XM_047447483.1 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
XM_024453356.1 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
XM_047447480.1 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
NM_001098210.1 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
XM_017005738.1 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
XM_006712985.2 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
XM_047447481.1 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
XM_047447478.1 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
NM_001904.4 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
NM_001098210 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
XM_005264886 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
XM_024453356.2 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
XM_017005738 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
XM_024453358.1 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
XM_024453357.1 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
NM_001098209 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
NM_001098209.1 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
XM_047447479.1 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
XM_006712985.1 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
NM_001904 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38
NM_001904.3 chr3:g.41224647_41224648insACAAGCAGC c.135_136insACAAGCAGC p.S45_L46insTSS RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References