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Gene APC
Variant F1354fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC F1354fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1354 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). F1354fs has not been characterized, however, due to the effects of other truncation mutations downstream of F1354 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC F1354fs

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Transcript NM_000038.6
gDNA chr5:g.(112839653_112839654)
cDNA c.(4060_4059)
Protein p.F1354fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000038.6 chr5:g.(112839653_112839654) c.(4060_4059) p.F1354fs RefSeq GRCh38/hg38
NM_000038.5 chr5:g.(112839653_112839654) c.(4060_4059) p.F1354fs RefSeq GRCh38/hg38
NM_000038 chr5:g.(112839653_112839654) c.(4060_4059) p.F1354fs RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.(112839653_112839654) c.(4060_4059) p.F1354fs RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.(112839653_112839654) c.(4060_4059) p.F1354fs RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.(112839653_112839654) c.(4060_4059) p.F1354fs RefSeq GRCh38/hg38
NM_001127510 chr5:g.(112839653_112839654) c.(4060_4059) p.F1354fs RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.(112839653_112839654) c.(4060_4059) p.F1354fs RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.(112839653_112839654) c.(4060_4059) p.F1354fs RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References