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Gene ATR
Variant L1361*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions ATR L1361* results in a premature truncation of the Atr protein at amino acid 1361 of 2644 (UniProt.org). Due to the loss of the PI3K/PI4K domain and the FATC domain (UniProt.org), L1361* is predicted to lead to a loss of Atr protein function.
Associated Drug Resistance
Category Variants Paths

ATR mutant ATR inact mut ATR L1361*

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Transcript NM_001184.4
gDNA chr3:g.142524063A>T
cDNA c.4082T>A
Protein p.L1361*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354579.2 chr3:g.142519776_142519778delCTTinsTAA c.4081_4083delCTTinsTAA p.L1361* RefSeq GRCh38/hg38
NM_001184.3 chr3:g.142524063A>T c.4082T>A p.L1361* RefSeq GRCh38/hg38
NM_001184.4 chr3:g.142524063A>T c.4082T>A p.L1361* RefSeq GRCh38/hg38
XM_047448360.1 chr3:g.142524063A>T c.4082T>A p.L1361* RefSeq GRCh38/hg38
XM_017006643 chr3:g.142519776_142519778delAAGinsTTA c.4081_4083delCTTinsTAA p.L1361* RefSeq GRCh38/hg38
XM_047448363.1 chr3:g.142524063A>T c.4082T>A p.L1361* RefSeq GRCh38/hg38
XM_047448361.1 chr3:g.142524063A>T c.4082T>A p.L1361* RefSeq GRCh38/hg38
XM_047448362.1 chr3:g.142524063A>T c.4082T>A p.L1361* RefSeq GRCh38/hg38
XM_011512924.2 chr3:g.142524063A>T c.4082T>A p.L1361* RefSeq GRCh38/hg38
NM_001184 chr3:g.142524063A>T c.4082T>A p.L1361* RefSeq GRCh38/hg38
XM_011512924.1 chr3:g.142524063A>T c.4082T>A p.L1361* RefSeq GRCh38/hg38
XM_011512924 chr3:g.142524063A>T c.4082T>A p.L1361* RefSeq GRCh38/hg38
NM_001354579.1 chr3:g.142519776_142519778delCTTinsTAA c.4081_4083delCTTinsTAA p.L1361* RefSeq GRCh38/hg38
XM_047448364.1 chr3:g.142524063A>T c.4082T>A p.L1361* RefSeq GRCh38/hg38
XM_011512926 chr3:g.142524063A>T c.4082T>A p.L1361* RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
ATR L1361* loss of function - predicted