TP53 S366Y
Gene Variant Detail

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Gene TP53
Variant S366Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 S366Y lies within HIPK1 and CARM1-interacting regions of the Tp53 protein (UniProt.org). S366Y has been identified in the scientific literature (PMID: 12826609), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Jun 2025).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon10 TP53 S366Y

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Transcript NM_000546.6
gDNA chr17:g.7670612G>T
cDNA c.1097C>A
Protein p.S366Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407264.1 chr17:g.7670612G>T c.1097C>A p.S366Y RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7670612G>T c.1097C>A p.S366Y RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7670612G>T c.1097C>A p.S366Y RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7670612G>T c.1097C>A p.S366Y RefSeq GRCh38/hg38
NM_001126112 chr17:g.7670612G>T c.1097C>A p.S366Y RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7670612G>T c.1097C>A p.S366Y RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7670612G>T c.1097C>A p.S366Y RefSeq GRCh38/hg38
NM_000546 chr17:g.7670612G>T c.1097C>A p.S366Y RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7670612G>T c.1097C>A p.S366Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References