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Gene TP53
Variant R335fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 R335fs results in a change in the amino acid sequence of the Tp53 protein beginning at aa 335 of 393, likely resulting in premature truncation of the functional protein (UniProt.org). R335fs has not been biochemically characterized however, due to the effects of truncation mutations downstream of R335 (PMID: 31081129, PMID: 34045312), is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon10 TP53 R335fs

TP53 mutant TP53 inact mut TP53 R335fs

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Transcript NM_000546.6
gDNA chr17:g.(7670706_7670707)
cDNA c.(1003_1002)
Protein p.R335fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000546 chr17:g.(7670706_7670707) c.(1003_1002) p.R335fs RefSeq GRCh38/hg38
NM_000546.6 chr17:g.(7670706_7670707) c.(1003_1002) p.R335fs RefSeq GRCh38/hg38
NM_000546.5 chr17:g.(7670706_7670707) c.(1003_1002) p.R335fs RefSeq GRCh38/hg38
NM_001126112 chr17:g.(7670706_7670707) c.(1003_1002) p.R335fs RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.(7670706_7670707) c.(1003_1002) p.R335fs RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.(7670706_7670707) c.(1003_1002) p.R335fs RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.(7670706_7670707) c.(1003_1002) p.R335fs RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.(7670706_7670707) c.(1003_1002) p.R335fs RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.(7670706_7670707) c.(1003_1002) p.R335fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries