KIT P577_E583dup
Gene Variant Detail

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Gene KIT
Variant P577_E583dup
Impact List duplication
Protein Effect unknown
Gene Variant Descriptions KIT P577_E583dup (also referred to as E583_F584insPYDHKWE) indicates the insertion of seven duplicate amino acids, proline (P)-577 through glutamic acid (E)-583, in the juxtamembrane domain (exon 11) of the Kit protein (PMID: 16226710). P577_E583dup has been identified in sequencing studies (PMID: 19768731), but has not been biochemically characterized and therefore, its effect on Kit protein function is unknown (PubMed, Nov 2025).
Associated Drug Resistance
Category Variants Paths

KIT mutant KIT exon11 KIT P577_E583dup

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Transcript NM_000222.3
gDNA chr4:g.54727497_54727517
cDNA c.1729_1749
Protein p.P577_E583
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017008178.1 chr4:g.54727497_54727517 c.1729_1749 p.P577_E583 RefSeq GRCh38/hg38
NM_000222 chr4:g.54727497_54727517 c.1729_1749 p.P577_E583 RefSeq GRCh38/hg38
NM_000222.2 chr4:g.54727497_54727517 c.1729_1749 p.P577_E583 RefSeq GRCh38/hg38
XM_017008178 chr4:g.54727497_54727517 c.1729_1749 p.P577_E583 RefSeq GRCh38/hg38
NM_001385285.1 chr4:g.54727497_54727517 c.1729_1749 p.P577_E583 RefSeq GRCh38/hg38
NM_000222.3 chr4:g.54727497_54727517 c.1729_1749 p.P577_E583 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
KIT P577_E583dup unknown