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Gene FGFR2
Variant K525E
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FGFR2 K525E (corresponds to K641E in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). K525E results in increased Fgfr2 autophosphorylation and substrate phosphorylation in in vitro kinase assays (PMID: 17803937).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 K525E

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Transcript NM_001144917.2
gDNA chr10:g.121488056T>C
cDNA c.1573A>G
Protein p.K525E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006717710.4 chr10:g.121500874T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
XM_006717708 chr10:g.121500868T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
XM_017015920 chr10:g.121500868T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121488056T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
XM_006717710.5 chr10:g.121500874T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121488056T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
NM_001144917 chr10:g.121488056T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
XM_006717710 chr10:g.121500874T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
XM_006717708.3 chr10:g.121500868T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
XM_017015920.2 chr10:g.121500868T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
XM_017015924 chr10:g.121496534T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
XM_006717708.4 chr10:g.121500868T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
XM_017015924.3 chr10:g.121496534T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
XM_017015924.2 chr10:g.121496534T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
XM_017015920.3 chr10:g.121500868T>C c.1573A>G p.K525E RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References