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Gene FGFR2
Variant K525E
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FGFR2 K525E (corresponds to K641E in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). K525E results in increased Fgfr2 autophosphorylation and substrate phosphorylation in in vitro kinase assays (PMID: 17803937).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 K525E

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Transcript NM_001144917.2
gDNA chr10:g.121488056T>C
cDNA c.1573A>G
Protein p.K525E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017015924.3 chr10:g.121496534T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
XM_006717708.4 chr10:g.121500868T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
XM_017015920 chr10:g.121500868T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
XM_017015924.2 chr10:g.121496534T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
XM_017015920.3 chr10:g.121500868T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
XM_006717710.4 chr10:g.121500874T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121488056T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
XM_017015924 chr10:g.121496534T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
XM_006717710.5 chr10:g.121500874T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
NM_001144917 chr10:g.121488056T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
XM_006717710 chr10:g.121500874T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
XM_017015920.2 chr10:g.121500868T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
XM_006717708 chr10:g.121500868T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
XM_006717708.3 chr10:g.121500868T>C c.1573A>G p.K525E RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121488056T>C c.1573A>G p.K525E RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
FGFR2 K525E gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor