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Gene FGFR2
Variant N549T
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FGFR2 N549T lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). N549T results in increased Fgfr2 autophosphorylation and substrate phosphorylation in in vitro kinase assays (PMID: 17803937).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 N549T

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Transcript NM_000141.5
gDNA chr10:g.121498521T>G
cDNA c.1646A>C
Protein p.N549T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141.5 chr10:g.121498521T>G c.1646A>C p.N549T RefSeq GRCh38/hg38
NM_001144915.2 chr10:g.121488064T>G c.1646A>C p.N549T RefSeq GRCh38/hg38
NM_001144919.2 chr10:g.121488067T>G c.1646A>C p.N549T RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121498521T>G c.1646A>C p.N549T RefSeq GRCh38/hg38
NM_023029.2 chr10:g.121488064T>G c.1646A>C p.N549T RefSeq GRCh38/hg38
NM_001144919.1 chr10:g.121488067T>G c.1646A>C p.N549T RefSeq GRCh38/hg38
NM_001144919 chr10:g.121488067T>G c.1646A>C p.N549T RefSeq GRCh38/hg38
NM_023029 chr10:g.121488064T>G c.1646A>C p.N549T RefSeq GRCh38/hg38
NM_001144915 chr10:g.121488064T>G c.1646A>C p.N549T RefSeq GRCh38/hg38
NM_001144915.1 chr10:g.121488064T>G c.1646A>C p.N549T RefSeq GRCh38/hg38
NM_000141 chr10:g.121498521T>G c.1646A>C p.N549T RefSeq GRCh38/hg38
NM_023029.2 chr10:g.121488064T>G c.1646A>C p.N549T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
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Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries