FGFR2 G663E
Gene Variant Detail

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Gene FGFR2
Variant G663E
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FGFR2 G663E lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). G663E results in increased Fgfr2 autophosphorylation and substrate phosphorylation in in vitro kinase assays (PMID: 17803937).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 G663E

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Transcript NM_000141.5
gDNA chr10:g.121487423C>T
cDNA c.1988G>A
Protein p.G663E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141.5 chr10:g.121487423C>T c.1988G>A p.G663E RefSeq GRCh38/hg38
NM_000141 chr10:g.121487423C>T c.1988G>A p.G663E RefSeq GRCh38/hg38
XM_017015921 chr10:g.121488040C>T c.1988G>A p.G663E RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121487423C>T c.1988G>A p.G663E RefSeq GRCh38/hg38
XM_017015921.3 chr10:g.121488040C>T c.1988G>A p.G663E RefSeq GRCh38/hg38
XM_017015921.2 chr10:g.121488040C>T c.1988G>A p.G663E RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References