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Gene FLT3
Variant F691I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FLT3 F691I lies within the protein kinase domain of the Flt3 protein (PMID: 23430109). F691I has been demonstrated to promote secondary drug resistance in the context of FLT3 internal tandem duplication (FLT3-ITD) mutations (PMID: 23392356, PMID: 22409268), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance Y
Category Variants Paths

FLT3 mutant FLT3 exon17 FLT3 F691I

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Transcript NM_004119.3
gDNA chr13:g.28027224A>T
cDNA c.2071T>A
Protein p.F691I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28027224A>T c.2071T>A p.F691I RefSeq GRCh38/hg38
XM_011535015.2 chr13:g.28027167A>T c.2071T>A p.F691I RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28027224A>T c.2071T>A p.F691I RefSeq GRCh38/hg38
XM_011535015 chr13:g.28027167A>T c.2071T>A p.F691I RefSeq GRCh38/hg38
NM_004119 chr13:g.28027224A>T c.2071T>A p.F691I RefSeq GRCh38/hg38
XM_011535015.3 chr13:g.28027167A>T c.2071T>A p.F691I RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References