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Gene PIK3CA
Variant G363A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA G363A lies within the C2 PI3K-type domain of the Pik3ca protein (UniProt.org). The functional effect of G363A is conflicting, as it demonstrates increased PI3K pathway signaling and moderate growth in culture (PMID: 23619167, PMID: 28528867) and increased cell migration (PMID: 34779417), however in other studies, results in cell proliferation levels, cell viability, and Akt phosphorylation similar to wild-type Pik3ca (PMID: 29533785, PMID: 34779417) and is not transforming in culture (PMID: 34779417), and therefore, its effect on Pik3ca protein function is unknown.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA G363A

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Transcript NM_006218.4
gDNA chr3:g.179204531G>C
cDNA c.1088G>C
Protein p.G363A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658.4 chr3:g.179204531G>C c.1088G>C p.G363A RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179204531G>C c.1088G>C p.G363A RefSeq GRCh38/hg38
NM_006218 chr3:g.179204531G>C c.1088G>C p.G363A RefSeq GRCh38/hg38
XM_011512894 chr3:g.179204531G>C c.1088G>C p.G363A RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179204531G>C c.1088G>C p.G363A RefSeq GRCh38/hg38
XM_006713658 chr3:g.179204531G>C c.1088G>C p.G363A RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179204531G>C c.1088G>C p.G363A RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179204531G>C c.1088G>C p.G363A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References