RAD51C G3R
Gene Variant Detail

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Gene RAD51C
Variant G3R
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions RAD51C G3R lies within a region of the Rad51c protein required for Holliday junction resolution activity (UniProt.org). G3R demonstrates intermediate homology-directed DNA repair activity in one study (PMID: 42625895), but results in functional homology-directed DNA repair activity in a different study (PMID: 37253112), retains binding to Rad51d and Xrcc3 similar to wild-type Rad51c in a yeast assay (PMID: 42625895), and rescues mitomycin C hypersensitivity and Rad51 foci formation similar to wild-type Rad51c in culture (PMID: 20400964), and therefore, is predicted to have no effect on Rad51c protein function.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C G3R

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Transcript NM_058216.3
gDNA chr17:g.58692650G>A
cDNA c.7G>A
Protein p.G3R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006722001 chr17:g.58692650G>A c.7G>A p.G3R RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58692650G>A c.7G>A p.G3R RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58692650G>A c.7G>A p.G3R RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58692650G>A c.7G>A p.G3R RefSeq GRCh38/hg38
NM_002876.4 chr17:g.58692650G>A c.7G>A p.G3R RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58692650G>A c.7G>A p.G3R RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58692650G>A c.7G>A p.G3R RefSeq GRCh38/hg38
NM_002876 chr17:g.58692650G>A c.7G>A p.G3R RefSeq GRCh38/hg38
NM_002876.3 chr17:g.58692650G>A c.7G>A p.G3R RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58692650G>A c.7G>A p.G3R RefSeq GRCh38/hg38
NM_058216 chr17:g.58692650G>A c.7G>A p.G3R RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58692650G>A c.7G>A p.G3R RefSeq GRCh38/hg38
XM_006722002 chr17:g.58692650G>A c.7G>A p.G3R RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References