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Gene | ROS1 |
Variant | S1986Y |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | ROS1 S1986Y lies within the protein kinase domain of the Ros1 protein (UniProt.org). S1986Y has been demonstrated to occur as a secondary drug resistance mutation in the context of ROS1 fusions (PMID: 27401242), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Apr 2024). |
Associated Drug Resistance | Y |
Category Variants Paths |
ROS1 mutant ROS1 S1986Y |
Transcript | NM_002944.3 |
gDNA | chr6:g.117318236G>T |
cDNA | c.5957C>A |
Protein | p.S1986Y |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_002944 | chr6:g.117318236G>T | c.5957C>A | p.S1986Y | RefSeq | GRCh38/hg38 |
NM_002944.2 | chr6:g.117318236G>T | c.5957C>A | p.S1986Y | RefSeq | GRCh38/hg38 |
NM_002944.3 | chr6:g.117318236G>T | c.5957C>A | p.S1986Y | RefSeq | GRCh38/hg38 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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