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Gene ROS1
Variant S1986Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 S1986Y lies within the protein kinase domain of the Ros1 protein (UniProt.org). S1986Y has been demonstrated to occur as a secondary drug resistance mutation in the context of ROS1 fusions (PMID: 27401242), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance Y
Category Variants Paths

ROS1 mutant ROS1 S1986Y

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Transcript NM_002944.3
gDNA chr6:g.117318236G>T
cDNA c.5957C>A
Protein p.S1986Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002944.2 chr6:g.117318236G>T c.5957C>A p.S1986Y RefSeq GRCh38/hg38
NM_002944.3 chr6:g.117318236G>T c.5957C>A p.S1986Y RefSeq GRCh38/hg38
NM_002944 chr6:g.117318236G>T c.5957C>A p.S1986Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ROS1 S1986Y Advanced Solid Tumor predicted - sensitive Foritinib Preclinical - Biochemical Actionable In a preclinical study, Foritinib inhibited kinase activity of a transformed cell line expressing ROS1 S1986Y in culture (PMID: 32918045). 32918045
ROS1 S1986Y Advanced Solid Tumor predicted - sensitive Lorlatinib Preclinical - Biochemical Actionable In a preclinical study, Lorbrena (lorlatinib) inhibited kinase activity of a transformed cell line expressing ROS1 S1986Y in culture (PMID: 32918045). 32918045