Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene TET2
Variant A1505T
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TET2 A1505T lies within the catalytic domain of the Tet2 protein (PMID: 24315485). A1505T confers a loss of function to the Tet2 protein as demonstrated by the inability of Tet2 to inhibit cell proliferation, lack of WT1 binding and regulation of WT1 target genes, and reduced enzymatic conversion of 5mC (PMID: 25601757).
Associated Drug Resistance
Category Variants Paths

TET2 mutant TET2 inact mut TET2 A1505T

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_001127208.3
gDNA chr4:g.105272894G>A
cDNA c.4513G>A
Protein p.A1505T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005263082.4 chr4:g.105272894G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
XM_005263082.3 chr4:g.105272894G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
NM_001127208.2 chr4:g.105272894G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
XM_006714242.4 chr4:g.105275323G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
XM_005263082 chr4:g.105272894G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
XM_024454103.1 chr4:g.105272894G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
NM_001127208 chr4:g.105272894G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
XM_024454102.1 chr4:g.105272894G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
XM_024454103.2 chr4:g.105272894G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
XM_006714242 chr4:g.105275323G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
XM_006714242.3 chr4:g.105275323G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
XM_024454102.2 chr4:g.105272894G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38
NM_001127208.3 chr4:g.105272894G>A c.4513G>A p.A1505T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries