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Gene TP53
Variant Y163H
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 Y163H lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). Y163H has been identified in the scientific literature (PMID: 27179933, PMID: 17764544, PMID: 28245875), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 Y163H

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Transcript NM_000546.6
gDNA chr17:g.7675125A>G
cDNA c.487T>C
Protein p.Y163H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407264.1 chr17:g.7675125A>G c.487T>C p.Y163H RefSeq GRCh38/hg38
NM_001126114 chr17:g.7675125A>G c.487T>C p.Y163H RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675125A>G c.487T>C p.Y163H RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7675125A>G c.487T>C p.Y163H RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7675125A>G c.487T>C p.Y163H RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7675125A>G c.487T>C p.Y163H RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7675125A>G c.487T>C p.Y163H RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675125A>G c.487T>C p.Y163H RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7675125A>G c.487T>C p.Y163H RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675125A>G c.487T>C p.Y163H RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675125A>G c.487T>C p.Y163H RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7675125A>G c.487T>C p.Y163H RefSeq GRCh38/hg38
NM_001126113 chr17:g.7675125A>G c.487T>C p.Y163H RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7675125A>G c.487T>C p.Y163H RefSeq GRCh38/hg38
NM_001126112 chr17:g.7675125A>G c.487T>C p.Y163H RefSeq GRCh38/hg38
NM_000546 chr17:g.7675125A>G c.487T>C p.Y163H RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7675125A>G c.487T>C p.Y163H RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 Y163H ovarian cancer sensitive APR-246 + Cisplatin Preclinical - Patient cell culture Actionable In a preclinical study, the combination of APR-246 and Platinol (cisplatin) resulted in strong synergism, thereby reducing cell viability in patient derived ovarian cancer cells harboring TP53 Y163H in culture (PMID: 27179933). 27179933