TP53 P278R
Gene Variant Detail

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Gene TP53
Variant P278R
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 P278R lies within the DNA-binding domain of the Tp53 protein (UniProt.org). P278R results in decreased transactivation of p21 in a reporter assay (PMID: 39140857) and in mouse cells (corresponding to P275R), results in failure to induce expression of Tp53 target genes p21 and Noxa in a reporter assay (PMID: 20195489), and therefore, is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon8 TP53 P278R

TP53 mutant TP53 inact mut TP53 P278R

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Transcript NM_000546.6
gDNA chr17:g.7673787G>C
cDNA c.833C>G
Protein p.P278R
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.