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Gene TP53
Variant P278R
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 P278R lies within the DNA-binding domain of the Tp53 protein (UniProt.org). P278R (corresponding to P275R in mouse) fails to induce expression of Tp53 target genes p21 and Noxa in a reporter assay (PMID: 20195489), and therefore, is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon8 TP53 P278R

TP53 mutant TP53 inact mut TP53 P278R

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Transcript NM_000546.6
gDNA chr17:g.7673787G>C
cDNA c.833C>G
Protein p.P278R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407266.1 chr17:g.7673787G>C c.833C>G p.P278R RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7673787G>C c.833C>G p.P278R RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7673787G>C c.833C>G p.P278R RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7673787G>C c.833C>G p.P278R RefSeq GRCh38/hg38
NM_001126114 chr17:g.7673787G>C c.833C>G p.P278R RefSeq GRCh38/hg38
NM_001126113 chr17:g.7673787G>C c.833C>G p.P278R RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7673787G>C c.833C>G p.P278R RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7673787G>C c.833C>G p.P278R RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7673787G>C c.833C>G p.P278R RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7673787G>C c.833C>G p.P278R RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7673787G>C c.833C>G p.P278R RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7673787G>C c.833C>G p.P278R RefSeq GRCh38/hg38
NM_000546 chr17:g.7673787G>C c.833C>G p.P278R RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7673787G>C c.833C>G p.P278R RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7673787G>C c.833C>G p.P278R RefSeq GRCh38/hg38
NM_001126112 chr17:g.7673787G>C c.833C>G p.P278R RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7673787G>C c.833C>G p.P278R RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 P278R ovarian cancer sensitive APR-246 + Cisplatin Preclinical - Patient cell culture Actionable In a preclinical study, the combination of APR-246 and Platinol (cisplatin) resulted in strong synergism, thereby reducing cell viability in patient derived ovarian cancer cells harboring TP53 P278R in culture (PMID: 27179933). 27179933