BTK T316A
Gene Variant Detail

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Gene BTK
Variant T316A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BTK T316A lies within the SH2 domain of the Btk protein (UniProt.org). T316A results in a partial increase in Btk autophosphorylation in an in vitro assay (PMID: 33226337), and confers resistance to Imbruvica (ibrutinib) in culture (PMID: 27626698), but has not been fully biochemically characterized, and therefore, its effect on Btk protein function is unknown.
Associated Drug Resistance Y
Category Variants Paths

BTK mutant BTK T316A

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Transcript NM_000061.3
gDNA chrX:g.101358645T>C
cDNA c.946A>G
Protein p.T316A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000061 chrX:g.101358645T>C c.946A>G p.T316A RefSeq GRCh38/hg38
NM_000061.2 chrX:g.101358645T>C c.946A>G p.T316A RefSeq GRCh38/hg38
NM_001287345.1 chrX:g.101358645T>C c.946A>G p.T316A RefSeq GRCh38/hg38
NM_000061.3 chrX:g.101358645T>C c.946A>G p.T316A RefSeq GRCh38/hg38
NM_001287345.2 chrX:g.101358645T>C c.946A>G p.T316A RefSeq GRCh38/hg38
NM_001287345 chrX:g.101358645T>C c.946A>G p.T316A RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References