FGFR3 V555L
Gene Variant Detail

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Gene FGFR3
Variant V555L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR3 V555L lies within the protein kinase domain of the Fgfr3 protein (UniProt.org). V555L has been demonstrated to confer resistance to Fgfr inhibitors in cell culture (PMID: 28034880, PMID: 37377403), but has not been biochemically characterized and therefore, its effect on Fgfr3 protein function is unknown (PubMed, Jul 2025).
Associated Drug Resistance Y
Category Variants Paths

FGFR3 mutant FGFR3 V555L

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Transcript NM_000142.5
gDNA chr4:g.1805767G>C
cDNA c.1663G>C
Protein p.V555L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047449823.1 chr4:g.1805767G>C c.1663G>C p.V555L RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.1805767G>C c.1663G>C p.V555L RefSeq GRCh38/hg38
NM_000142 chr4:g.1805767G>C c.1663G>C p.V555L RefSeq GRCh38/hg38
XM_006713871.1 chr4:g.1805761G>C c.1663G>C p.V555L RefSeq GRCh38/hg38
XM_006713873.1 chr4:g.1805767G>C c.1663G>C p.V555L RefSeq GRCh38/hg38
XM_011513420.1 chr4:g.1805761G>C c.1663G>C p.V555L RefSeq GRCh38/hg38
NM_001163213 chr4:g.1805761G>C c.1663G>C p.V555L RefSeq GRCh38/hg38
NM_001163213.2 chr4:g.1805761G>C c.1663G>C p.V555L RefSeq GRCh38/hg38
NM_000142.5 chr4:g.1805767G>C c.1663G>C p.V555L RefSeq GRCh38/hg38
XM_006713873 chr4:g.1805767G>C c.1663G>C p.V555L RefSeq GRCh38/hg38
XM_006713871 chr4:g.1805761G>C c.1663G>C p.V555L RefSeq GRCh38/hg38
NM_000142.4 chr4:g.1805767G>C c.1663G>C p.V555L RefSeq GRCh38/hg38
XM_006713871.2 chr4:g.1805761G>C c.1663G>C p.V555L RefSeq GRCh38/hg38
XM_011513420.2 chr4:g.1805761G>C c.1663G>C p.V555L RefSeq GRCh38/hg38
XM_006713873.2 chr4:g.1805767G>C c.1663G>C p.V555L RefSeq GRCh38/hg38
NM_001163213.1 chr4:g.1805761G>C c.1663G>C p.V555L RefSeq GRCh38/hg38
XM_011513420 chr4:g.1805761G>C c.1663G>C p.V555L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 V555L Advanced Solid Tumor decreased response Infigratinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells over expressing FGFR3 V555L demonstrated reduced sensitivity to Truseltiq (infigratinib) in culture (PMID: 28034880). 28034880
FGFR3 V555L transitional cell carcinoma resistant Infigratinib Case Reports/Case Series Actionable In a clinical study, two patients with metastatic urothelial carcinoma progressed while being treated with Truseltiq (infigratinib) and subsequent cell-free DNA testing revealed FGFR3 V555L (also corresponds to V443L) (PMID: 29848605). 29848605