FGFR2 V564I
Gene Variant Detail

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Gene FGFR2
Variant V564I
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FGFR2 V564I lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). V564I confers a gain of function to the Fgfr2 protein as indicated by increased Fgfr2 kinase activity (PMID: 25169980), results in FGF2-independent phosphorylation of Akt and Erk in cell culture (PMID: 29540482), and has been shown to be associated with secondary resistance to FGFR inhibitors (PMID: 25169980).
Associated Drug Resistance Y
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 V564I

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Transcript NM_000141.5
gDNA chr10:g.121496705C>T
cDNA c.1690G>A
Protein p.V564I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144916 chr10:g.121487376C>T c.1690G>A p.V564I RefSeq GRCh38/hg38
NM_001144916.2 chr10:g.121487376C>T c.1690G>A p.V564I RefSeq GRCh38/hg38
NM_000141 chr10:g.121496705C>T c.1690G>A p.V564I RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121496705C>T c.1690G>A p.V564I RefSeq GRCh38/hg38
NM_001144916.1 chr10:g.121487376C>T c.1690G>A p.V564I RefSeq GRCh38/hg38
XM_024447887.1 chr10:g.121488077C>T c.1690G>A p.V564I RefSeq GRCh38/hg38
XM_024447887.2 chr10:g.121488077C>T c.1690G>A p.V564I RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121496705C>T c.1690G>A p.V564I RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries