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Gene FGFR2
Variant V564M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 V564M lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). V564M has been demonstrated to confer resistance to Fgfr inhibitors in culture (PMID: 25349422), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance Y
Category Variants Paths

FGFR2 mutant FGFR2 V564M

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Transcript NM_000141.5
gDNA chr10:g.121496703_121496705delGTTinsATG
cDNA c.1690_1692delGTTinsATG
Protein p.V564M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144916.1 chr10:g.121487374_121487376delGTAinsATG c.1690_1692delGTAinsATG p.V564M RefSeq GRCh38/hg38
XM_024447887.1 chr10:g.121488075_121488077delGTAinsATG c.1690_1692delGTAinsATG p.V564M RefSeq GRCh38/hg38
NM_001144916 chr10:g.121487374_121487376delTACinsCAT c.1690_1692delGTAinsATG p.V564M RefSeq GRCh38/hg38
NM_001144916.2 chr10:g.121487374_121487376delGTAinsATG c.1690_1692delGTAinsATG p.V564M RefSeq GRCh38/hg38
NM_000141 chr10:g.121496703_121496705delAACinsCAT c.1690_1692delGTTinsATG p.V564M RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121496703_121496705delGTTinsATG c.1690_1692delGTTinsATG p.V564M RefSeq GRCh38/hg38
XM_024447887.2 chr10:g.121488075_121488077delGTAinsATG c.1690_1692delGTAinsATG p.V564M RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121496703_121496705delGTTinsATG c.1690_1692delGTTinsATG p.V564M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
FGFR2 V564M unknown