APC A1508V
Gene Variant Detail

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Gene APC
Variant A1508V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions APC A1508V lies within the beta-catenin binding and downregulation region of the Apc protein (PMID: 14672538). A1508V has been identified in sequencing studies (PMID: 20569184), but has not been biochemically characterized and therefore, its effect on Apc protein function is unknown (PubMed, Nov 2025).
Associated Drug Resistance
Category Variants Paths

APC mutant APC A1508V

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Transcript NM_000038.6
gDNA chr5:g.112840117C>T
cDNA c.4523C>T
Protein p.A1508V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354895.2 chr5:g.112840117C>T c.4523C>T p.A1508V RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112840117C>T c.4523C>T p.A1508V RefSeq GRCh38/hg38
NM_000038 chr5:g.112840117C>T c.4523C>T p.A1508V RefSeq GRCh38/hg38
NM_001127510 chr5:g.112840117C>T c.4523C>T p.A1508V RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112840117C>T c.4523C>T p.A1508V RefSeq GRCh38/hg38
NM_001407471.1 chr5:g.112841269C>T c.4523C>T p.A1508V RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112840117C>T c.4523C>T p.A1508V RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112840117C>T c.4523C>T p.A1508V RefSeq GRCh38/hg38
NM_001407457.1 chr5:g.112840366C>T c.4523C>T p.A1508V RefSeq GRCh38/hg38
NM_001407455.1 chr5:g.112840366C>T c.4523C>T p.A1508V RefSeq GRCh38/hg38
NM_001407456.1 chr5:g.112840366C>T c.4523C>T p.A1508V RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112840117C>T c.4523C>T p.A1508V RefSeq GRCh38/hg38
NM_001407454.1 chr5:g.112840366C>T c.4523C>T p.A1508V RefSeq GRCh38/hg38
NM_001407472.1 chr5:g.112841269C>T c.4523C>T p.A1508V RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112840117C>T c.4523C>T p.A1508V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
APC A1508V unknown