BTK T474I
Gene Variant Detail

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Gene BTK
Variant T474I
Impact List missense
Protein Effect no effect
Gene Variant Descriptions BTK T474I lies within the protein kinase domain of the Btk protein (UniProt.org). T474I demonstrates kinase activity similar to wild-type Btk in cultured cells (PMID: 27571029, PMID: 28573668, PMID: 33526860).
Associated Drug Resistance
Category Variants Paths

BTK mutant BTK T474I

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Transcript NM_000061.3
gDNA chrX:g.101356197G>A
cDNA c.1421C>T
Protein p.T474I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000061.3 chrX:g.101356197G>A c.1421C>T p.T474I RefSeq GRCh38/hg38
NM_000061.2 chrX:g.101356197G>A c.1421C>T p.T474I RefSeq GRCh38/hg38
NM_000061 chrX:g.101356197G>A c.1421C>T p.T474I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
BTK T474I no effect
BTK T474I BTK C481S
BTK T474I BTK C481S BTK L528W
BTK T474I BTK C481R
BTK T474I BTK L528W
BTK E108K BTK T474I BTK C481S BTK L528W